Coffee polyphenol consumption improves postprandial hyperglycemia associated with impaired vascular endothelial function in healthy male adults

Nutr Res. 2015 Oct;35(10):873-881. doi: 10.1016/j.nutres.2015.07.005. Epub 2015 Aug 4.


Epidemiological studies indicate that habitual coffee consumption lowers the risk of diabetes and cardiovascular diseases. Postprandial hyperglycemia is a direct and independent risk factor for cardiovascular diseases. We previously demonstrated that coffee polyphenol ingestion increased secretion of Glucagon-like peptide 1 (GLP-1), which has been shown to exhibit anti-diabetic and cardiovascular effects. We hypothesized coffee polyphenol consumption may improve postprandial hyperglycemia and vascular endothelial function by increasing GLP-1 release and/or reducing oxidative stress. To examine this hypothesis, we conducted a randomized, acute, crossover, intervention study in healthy male adults, measuring blood parameters and flow-mediated dilation (FMD) after ingestion of a meal with or without coffee polyphenol extract (CPE). Nineteen subjects consumed a test meal with either a placebo- or CPE-containing beverage. Blood biomarkers and FMD were measured at fasting and up to 180 minutes postprandially. The CPE beverage led to a significantly lower peak postprandial increase in blood glucose and diacron-reactive oxygen metabolite, and significantly higher postprandial FMD than the placebo beverage. Postprandial blood GLP-1 increase tended to be higher after ingestion of the CPE beverage, compared with placebo. Subclass analysis revealed that the CPE beverage significantly improved postprandial blood GLP-1 response and reduced blood glucose increase in the subjects with a lower insulinogenic index. Correlation analysis showed postprandial FMD was negatively associated with blood glucose increase after ingestion of the CPE beverage. In conclusion, these results suggest that coffee polyphenol consumption improves postprandial hyperglycemia and vascular endothelial function, which is associated with increased GLP-1 secretion and decreased oxidative stress in healthy humans.

Keywords: Blood glucose; Coffee polyphenol; Flow-mediated dilatation; GLP-1; Insulin.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Blood Glucose / analysis
  • Coffea / chemistry*
  • Endothelium, Vascular / drug effects*
  • Endothelium, Vascular / physiopathology
  • Glucagon-Like Peptide 1 / blood
  • Hot Temperature
  • Humans
  • Hyperglycemia / physiopathology
  • Hyperglycemia / prevention & control*
  • Japan
  • Male
  • Middle Aged
  • Oxidative Stress / drug effects
  • Placebos
  • Plant Extracts / administration & dosage
  • Polyphenols / administration & dosage*
  • Seeds / chemistry
  • Single-Blind Method


  • Blood Glucose
  • Placebos
  • Plant Extracts
  • Polyphenols
  • Glucagon-Like Peptide 1