rs4771122 Predicts Multiple Measures of Long-Term Weight Loss After Bariatric Surgery

doi:10.1007/s11695-015-1872-7

. 2015 Nov;25(11):2225-9.

doi: 10.1007/s11695-015-1872-7.

rs4771122 Predicts Multiple Measures of Long-Term Weight Loss After Bariatric Surgery

Affiliations

¹ Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, 680 N. Lakeshore Drive, Suite 1400, Chicago, IL, 60611, USA. ljrtorvik@northwestern.edu.
² Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, 680 N. Lakeshore Drive, Suite 1400, Chicago, IL, 60611, USA.
³ Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
⁴ NorthShore Research Institute, NorthShore University Health System, Evanston, IL, USA.
⁵ Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

PMID: 26337695
PMCID: PMC4598314
DOI: 10.1007/s11695-015-1872-7

rs4771122 Predicts Multiple Measures of Long-Term Weight Loss After Bariatric Surgery

Laura J Rasmussen-Torvik et al. Obes Surg. 2015 Nov.

. 2015 Nov;25(11):2225-9.

doi: 10.1007/s11695-015-1872-7.

Affiliations

¹ Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, 680 N. Lakeshore Drive, Suite 1400, Chicago, IL, 60611, USA. ljrtorvik@northwestern.edu.
² Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, 680 N. Lakeshore Drive, Suite 1400, Chicago, IL, 60611, USA.
³ Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
⁴ NorthShore Research Institute, NorthShore University Health System, Evanston, IL, USA.
⁵ Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

PMID: 26337695
PMCID: PMC4598314
DOI: 10.1007/s11695-015-1872-7

Abstract

We examined the association of 34 single nucleotide polymorphisms with weight loss up to 9.5 years after Roux-en-Y surgery. Participants were enrollees in the NUgene biobank with stored DNA and linked electronic health records. Ninety-five self-identified white participants underwent surgery and had follow-up weights obtained between 1 and 9.5 years after surgery. SNP rs4771122 was the variant most significantly associated with long-term weight loss after surgery in a repeated linear mixed model (p = .004) of long-term weight loss. In this model, each additional copy of the minor allele was associated with nearly 5 % greater percentage weight loss. This same SNP was also nominally significantly (p < .05) associated with weight loss trajectories, weight loss nadir, and weight loss 2 years after surgery.

Keywords: Bariatric surgery; Long-term weight loss; Obesity GWAS; Predictors; Repeated measures; Roux-en-Y gastric bypass; SNP.

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Conflict of interest statement

CONFLICT OF INTEREST

Laura Rasmussen-Torvik, no conflict of interest

Abigail S. Baldridge, no conflict of interest

Jennifer A. Pacheco, no conflict of interest

Sharon A Aufox, no conflict of interest

Kwang-Youn A. Kim, no conflict of interest

Jonathan C Silverstein, no conflict of interest

Erwin W Denham, no conflict of interest

Eric Hungness, no conflict of interest

Maureen E Smith, no conflict of interest

Philip Greenland, no conflict of interest

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[1] Still CD, Wood GC, Chu X, Erdman R, Manney CH, Benotti PN, Petrick AT, Strodel WE, Mirshahi UL, Mirshahi T, Carey DJ, Gerhard GS. High Allelic Burden of Four Obesity SNPs Is Associated With Poorer Weight Loss Outcomes Following Gastric Bypass Surgery. Obesity (Silver Spring) 2011 doi: 10.1038/oby.2011.3. Epub 2011/02/12 oby20113 [pii] - DOI - PubMed

[2] Still CD, Wood GC, Chu X, Erdman R, Manney CH, Benotti PN, Petrick AT, Strodel WE, Mirshahi UL, Mirshahi T, Carey DJ, Gerhard GS. High Allelic Burden of Four Obesity SNPs Is Associated With Poorer Weight Loss Outcomes Following Gastric Bypass Surgery. Obesity (Silver Spring) 2011 doi: 10.1038/oby.2011.3. Epub 2011/02/12 oby20113 [pii] - DOI - PubMed

[3] Kakela P, Jaaskelainen T, Torpstrom J, Ilves I, Venesmaa S, Paakkonen M, Gylling H, Paajanen H, Uusitupa M, Pihlajamaki J. Genetic risk score does not predict the outcome of obesity surgery. Obes Surg. 2014;24(1):128–33. doi: 10.1007/s11695-013-1080-2. - DOI - PubMed

[4] Kakela P, Jaaskelainen T, Torpstrom J, Ilves I, Venesmaa S, Paakkonen M, Gylling H, Paajanen H, Uusitupa M, Pihlajamaki J. Genetic risk score does not predict the outcome of obesity surgery. Obes Surg. 2014;24(1):128–33. doi: 10.1007/s11695-013-1080-2. - DOI - PubMed

[5] Sarzynski MA, Jacobson P, Rankinen T, Carlsson B, Sjostrom L, Bouchard C, Carlsson LM. Associations of markers in 11 obesity candidate genes with maximal weight loss and weight regain in the SOS bariatric surgery cases. Int J Obes (Lond) 2010 doi: 10.1038/ijo.2010.166. Epub 2010/08/25 ijo2010166 [pii] - DOI - PubMed

[6] Sarzynski MA, Jacobson P, Rankinen T, Carlsson B, Sjostrom L, Bouchard C, Carlsson LM. Associations of markers in 11 obesity candidate genes with maximal weight loss and weight regain in the SOS bariatric surgery cases. Int J Obes (Lond) 2010 doi: 10.1038/ijo.2010.166. Epub 2010/08/25 ijo2010166 [pii] - DOI - PubMed

[7] Baldridge AS, Pacheco JA, Aufox SA, Kim KA, Silverstein JC, Denham W, Hungness E, Smith ME, Allen NB, Greenland P, Rasmussen-Torvik LJ. Factors Associated With Long-Term Weight Loss Following Bariatric Surgery Using 2 Methods for Repeated Measures Analysis. Am J Epidemiol. 2015 doi: 10.1093/aje/kwv039. In Press. - DOI - PMC - PubMed

[8] Baldridge AS, Pacheco JA, Aufox SA, Kim KA, Silverstein JC, Denham W, Hungness E, Smith ME, Allen NB, Greenland P, Rasmussen-Torvik LJ. Factors Associated With Long-Term Weight Loss Following Bariatric Surgery Using 2 Methods for Repeated Measures Analysis. Am J Epidemiol. 2015 doi: 10.1093/aje/kwv039. In Press. - DOI - PMC - PubMed

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rs4771122 Predicts Multiple Measures of Long-Term Weight Loss After Bariatric Surgery

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rs4771122 Predicts Multiple Measures of Long-Term Weight Loss After Bariatric Surgery

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