Acitretin-induced spiny follicular hyperkeratosis

Cutan Ocul Toxicol. 2016;35(2):165-7. doi: 10.3109/15569527.2015.1072545. Epub 2015 Aug 12.


Spiny follicular hyperkeratosis (SFH) is follicular flesh-colored hyperkeratotic spicules that are linked to different situations including drug reactions. Previously suspected drugs are BRAF inhibitors and cyclosporine. We described a 51-year-old psoriasis patient with SFH who had been using acitretin.

Keywords: Acitretin; side effect; spiny follicular hyperkeratosis.

Publication types

  • Case Reports

MeSH terms

  • Acitretin / adverse effects*
  • Acitretin / therapeutic use
  • Female
  • Humans
  • Keratolytic Agents / adverse effects*
  • Keratolytic Agents / therapeutic use
  • Keratosis / chemically induced*
  • Middle Aged
  • Psoriasis / drug therapy


  • Keratolytic Agents
  • Acitretin