C282Y and H63D Polymorphisms in Hemochromatosis Gene and Risk of Parkinson's Disease: A Meta-Analysis

Am J Alzheimers Dis Other Demen. 2016 May;31(3):201-7. doi: 10.1177/1533317515602220. Epub 2015 Sep 3.


Objective: A meta-analysis was performed to better clarify the association between hemochromatosis (HFE) gene and the risk of Parkinson's disease (PD).

Methods: Pooled odds ratio (OR) with 95% confidence interval (CI) was calculated from fixed- and random-effect models. Heterogeneity among studies was evaluated using the I(2) and Q test. Egger's test was used to estimate the publication bias.

Results: We identified 8 articles with 9 independent studies for this meta-analysis. The present meta-analysis showed no significant association of Y allele with the risk of PD in dominant (OR = 0.87, 95% CI = 0.70-1.09), recessive (OR = 1.58, 95% CI = 0.61-4.10), and codominant (OR = 0.88, 95% CI = 0.72-1.09) models for C282Y. There were also no significant associations of D allele with the risk of PD in dominant (OR = 1.04, 95% CI = 0.87-1.24), recessive (OR = 1.23, 95% CI = 0.70-2.18), and codominant (OR = 1.04, 95% CI = 0.89-1.22) genetic models for H63D. No publication bias was detected.

Conclusion: The meta-analysis indicated that C282Y and H63D polymorphisms in the HFE gene might not be associated with PD.

Keywords: Parkinson’s disease; gene; hemochromatosis; meta-analysis.

Publication types

  • Meta-Analysis

MeSH terms

  • Hemochromatosis Protein / genetics*
  • Humans
  • Parkinson Disease / genetics*


  • HFE protein, human
  • Hemochromatosis Protein