Ebola virus dynamics in mice treated with favipiravir

Antiviral Res. 2015 Nov;123:70-7. doi: 10.1016/j.antiviral.2015.08.015. Epub 2015 Sep 2.

Abstract

The polymerase inhibitor favipiravir is a candidate for the treatment of Ebola virus disease. Here, we designed a mathematical model to characterize the viral dynamics in 20 mice experimentally infected with Ebola virus, which were either left untreated or treated with favipiravir at 6 or 8days post infection. This approach provided estimates of kinetic parameters of Ebola virus reproduction, such as the half-life of productively infected cells, of about 6h, and the basic reproductive number which indicates that virus produced by a single infected cell productively infects about 9 new cells. Furthermore, the model predicted that favipiravir efficiently blocks viral production, reaching an antiviral effectiveness of 95% and 99.6% at 2 and 6days after initiation of treatment, respectively. The model could be particularly helpful to guide future studies evaluating favipiravir in larger animals.

Keywords: Ebola; Favipiravir; Modeling; Viral kinetics.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amides / administration & dosage*
  • Animals
  • Antiviral Agents / administration & dosage*
  • Disease Models, Animal
  • Ebolavirus / growth & development*
  • Ebolavirus / isolation & purification
  • Female
  • Hemorrhagic Fever, Ebola / drug therapy*
  • Hemorrhagic Fever, Ebola / virology*
  • Mice, Inbred C57BL
  • Models, Theoretical
  • Pyrazines / administration & dosage*
  • Survival Analysis
  • Viral Load*

Substances

  • Amides
  • Antiviral Agents
  • Pyrazines
  • favipiravir