The effect of bariatric surgery on gastrointestinal and pancreatic peptide hormones

Peptides. 2016 Mar;77:28-37. doi: 10.1016/j.peptides.2015.08.013. Epub 2015 Sep 5.


Bariatric surgery for obesity has proved to be an extremely effective method of promoting long-term weight reduction with additional beneficial metabolic effects, such as improved glucose tolerance and remission of type 2 diabetes. A range of bariatric procedures are in common use, including gastric banding, sleeve gastrectomy and the Roux-en-Y gastric bypass. Although the mechanisms underlying the efficacy of bariatric surgery are unclear, gastrointestinal and pancreatic peptides are thought to play an important role. The aim of this review is to summarise the effects of different bariatric surgery procedures upon gastrointestinal and pancreatic peptides, including ghrelin, gastrin, cholecystokinin (CCK), glucose-dependent insulinotropic hormone (GIP), glucagon-like peptide 1 (GLP-1), peptide YY (PYY), oxyntomodulin, insulin, glucagon and somatostatin.

Keywords: Bariatric; Cholecystokinin; Gastrin; Ghrelin; Incretin; Oxyntomodulin.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Appetite
  • Bariatric Surgery*
  • Gastrointestinal Hormones / metabolism*
  • Gastrointestinal Tract / metabolism
  • Humans
  • Obesity / metabolism
  • Obesity / surgery
  • Pancreas / metabolism
  • Pancreatic Hormones / metabolism*


  • Gastrointestinal Hormones
  • Pancreatic Hormones