[The action of strophanthin K and beta-acetyldigoxin in vitro on the energy transformation by the contractile protein system of the normal cardiomyocyte]

N V Karsanov; T N Macharashvili; V A Magaldadze

[The action of strophanthin K and beta-acetyldigoxin in vitro on the energy transformation by the contractile protein system of the normal cardiomyocyte]

Biull Eksp Biol Med. 1989 Dec;108(12):686-9.

[Article in Russian]

Authors

N V Karsanov, T N Macharashvili, V A Magaldadze

PMID: 2634440

Abstract

It was shown in experiments on myocardial fiber bundles (MGFB) from normal heart that strophantin K and beta-acetildigoxin in vitro in concentration of 10(-6) M sharply increased the value of force generated by contractile protein system and its ability to perform work. In this case strophantin K significantly increased energy transformation efficiency. It was concluded that in myocardial contractile protein system a regulator of qualitative and quantitative energy transformation is functioning (a kind of economizer).

Publication types

Comparative Study

MeSH terms

Acetyldigoxins / pharmacology*
Animals
Digoxin / analogs & derivatives*
Energy Metabolism / drug effects*
Energy Metabolism / physiology
Heart / drug effects*
In Vitro Techniques
Muscle Proteins / drug effects*
Muscle Proteins / metabolism
Myocardium / metabolism*
Rabbits
Reference Values
Strophanthins / pharmacology*
Thermodynamics

Substances

Acetyldigoxins
Muscle Proteins
Strophanthins
Digoxin
strophanthin K