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. 2015 Dec 4;175:30-8.
doi: 10.1016/j.jep.2015.08.048. Epub 2015 Sep 4.

Inhalation of Cedrus Atlantica Essential Oil Alleviates Pain Behavior Through Activation of Descending Pain Modulation Pathways in a Mouse Model of Postoperative Pain

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Inhalation of Cedrus Atlantica Essential Oil Alleviates Pain Behavior Through Activation of Descending Pain Modulation Pathways in a Mouse Model of Postoperative Pain

Daniel F Martins et al. J Ethnopharmacol. .

Abstract

Ethnopharmacological relevance: Cedrus atlantica essential oil (CaEO) presents analgesic and anti-inflammatory sedative properties. However, it remains unknown whether CaEO alleviates acute postoperative pain.

Materials and methods: Here, we investigated the effect of CaEO on postoperative pain and its mechanisms related to the descending pain control in Swiss males mice induced by a plantar incision surgery (PIS) in the hindpaw.

Results: Inhalation of CaEO (5', 30' or 60') markedly reduced mechanical hypersensitivity. This effect was prevented by pre-treatment with naloxone or p-chlorophenylalanine methyl ester (PCPA, 100mg/kg, i.p.)-induced depletion of serotonin. In addition, p-alpha-methyl-para-tyrosin (AMPT, 100mg/kg, i.p.)-induced depletion of norepinephrine, intraperitoneal injection of the α2-adrenergic receptor antagonist yohimbine (0.15 mg/kg, i.p.) or haloperidol (1mg/kg, i.p.) an antagonist of dopaminergic (D1 and D2) receptors prevented the effect of CaEO on hypersensitivity.

Conclusions: These findings suggest that CaEO alleviates postoperative pain by activating the descending pain modulation pathways on the opioidergic, serotonergic, noradrenergic (α2-adrenergic) and dopaminergic (dopamine D1 and D2 receptors) systems.

Keywords: Aromatherapy; Ethnopharmacology; Incisional Pain; Mice; Surgery.

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