The relation between celiac disease, nonceliac gluten sensitivity and irritable bowel syndrome

Nutr J. 2015 Sep 7;14:92. doi: 10.1186/s12937-015-0080-6.


Wheat products make a substantial contribution to the dietary intake of many people worldwide. Despite the many beneficial aspects of consuming wheat products, it is also responsible for several diseases such as celiac disease (CD), wheat allergy, and nonceliac gluten sensitivity (NCGS). CD and irritable bowel syndrome (IBS) patients have similar gastrointestinal symptoms, which can result in CD patients being misdiagnosed as having IBS. Therefore, CD should be excluded in IBS patients. A considerable proportion of CD patients suffer from IBS symptoms despite adherence to a gluten-free diet (GFD). The inflammation caused by gluten intake may not completely subside in some CD patients. It is not clear that gluten triggers the symptoms in NCGS, but there is compelling evidence that carbohydrates (fructans and galactans) in wheat does. It is likely that NCGS patients are a group of self-diagnosed IBS patients who self-treat by adhering to a GFD.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Celiac Disease / diagnosis*
  • Diet, Gluten-Free
  • Food Hypersensitivity / diagnosis*
  • Glutens / adverse effects*
  • Humans
  • Inflammation / diagnosis
  • Irritable Bowel Syndrome / diagnosis*
  • Randomized Controlled Trials as Topic
  • Triticum / chemistry


  • Glutens