Candida albicans commensalism in the gastrointestinal tract

FEMS Yeast Res. 2015 Nov;15(7):fov081. doi: 10.1093/femsyr/fov081. Epub 2015 Sep 6.


Candida albicans is a polymorphic yeast species that often forms part of the commensal gastrointestinal mycobiota of healthy humans. It is also an important opportunistic pathogen. A tripartite interaction involving C. albicans, the resident microbiota and host immunity maintains C. albicans in its commensal form. The influence of each of these factors on C. albicans carriage is considered herein, with particular focus on the mycobiota and the approaches used to study it, models of gastrointestinal colonization by C. albicans, the C. albicans genes and phenotypes that are necessary for commensalism and the host factors that influence C. albicans carriage.

Keywords: Candida albicans; animal models; commensalism; gastrointestinal tract; immunity; microbiota; mycobiota.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Candida albicans / immunology
  • Candida albicans / physiology*
  • Carrier State / microbiology*
  • Gastrointestinal Microbiome
  • Gastrointestinal Tract / microbiology*
  • Host-Pathogen Interactions
  • Humans
  • Microbial Interactions
  • Models, Animal
  • Symbiosis*