Copper-Catalyzed sp(3) C-H Aminative Cyclization of 2-Alkyl-N-arylbenzamides: An Approach for the Synthesis of N-Aryl-isoindolinones

Kanako Nozawa-Kumada; Jun Kadokawa; Takehiro Kameyama; Yoshinori Kondo

doi:10.1021/acs.orglett.5b02235

Copper-Catalyzed sp(3) C-H Aminative Cyclization of 2-Alkyl-N-arylbenzamides: An Approach for the Synthesis of N-Aryl-isoindolinones

Org Lett. 2015 Sep 18;17(18):4479-81. doi: 10.1021/acs.orglett.5b02235. Epub 2015 Sep 8.

Authors

Kanako Nozawa-Kumada¹, Jun Kadokawa¹, Takehiro Kameyama¹, Yoshinori Kondo¹

Affiliation

¹ Graduate School of Pharmaceutical Sciences, Tohoku University , 6-3, Aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan.

PMID: 26348773
DOI: 10.1021/acs.orglett.5b02235

Abstract

The synthesis of isoindolinones via copper-catalyzed sp(3) C-H functionalization of 2-alkyl-N-substituted benzamides is described. This process does not require the preparation of halogenated substitutes, expensive transition metals, or toxic Sn or CO gas. This method provides an efficient approach to generate various functionalized isoindolinones.

Publication types

Research Support, Non-U.S. Gov't