Diffusion-weighted magnetic resonance imaging in patients with prostate cancer treated with radiotherapy

Tumori. 2016 Jan-Feb;102(1):71-6. doi: 10.5301/tj.5000415. Epub 2015 Sep 4.


Aims: To evaluate the utility of a multiparametric 3T magnetic resonance imaging (MRI) study using diffusion-weighted images (DWI) for the assessment of prostate cancer before and after radiotherapy (RT).

Methods: A total of 34 patients, who received a histologic diagnosis of prostate adenocarcinoma, underwent MRI examination before and after local RT for the assessment of response to treatment. Apparent diffusion coefficient (ADC) values were calculated and compared.

Results: Before RT, DWI shows pathologic restriction of signal, while after RT pathologic restriction of signal was reduced or disappeared. The ADC values were significantly increased after therapy (p<0.05).

Conclusions: The use of DWI with ADC measurements may be an imaging biomarker in the assessment of prostate cancer.

MeSH terms

  • Adenocarcinoma / blood
  • Adenocarcinoma / pathology*
  • Adenocarcinoma / radiotherapy*
  • Aged
  • Aged, 80 and over
  • Biomarkers, Tumor / blood
  • Diffusion Magnetic Resonance Imaging* / methods
  • Feasibility Studies
  • Humans
  • Male
  • Neoplasm Grading
  • Prospective Studies
  • Prostate-Specific Antigen / blood
  • Prostatic Neoplasms / blood
  • Prostatic Neoplasms / pathology*
  • Prostatic Neoplasms / radiotherapy*
  • Reproducibility of Results
  • Sample Size
  • Treatment Outcome


  • Biomarkers, Tumor
  • Prostate-Specific Antigen