Diffusion-weighted whole-body imaging with background body signal suppression/T2 image fusion and positron emission tomography/computed tomography of upper gastrointestinal cancers

Abdom Imaging. 2015 Oct;40(8):3012-9. doi: 10.1007/s00261-015-0545-2.


Purpose: Diffusion-weighted whole-body imaging with background body signal suppression/T2 image fusion (DWIBS/T2) strongly contrasts cancerous tissue against background healthy tissues. Positron emission tomography/computed tomography (PET/CT) applies the uptake of 18-fluorodeoxyglucose in the diagnosis of cancer. Our aim was to compare DWIBS/T2 and PET/CT in patients with upper gastrointestinal cancers.

Methods: Patient records, including imaging results from July 2012 to March 2015, were analyzed retrospectively. Four men (age, 72.5 ± 5.3 years) and ten women (age, 71.6 ± 4.0 years) were enrolled in this study. The numbers of patients with esophageal cancer, gastric cancer, gastrointestinal stromal tumor, and duodenal cancer were one, eight, three, and two, respectively.

Results: Six out of eight patients with gastric cancer had positive results on both DWIBS/T2 and PET/CT. The diameter and depth of invasion of gastric cancer was larger in patients with positive DWIBS/T2 and PET/CT findings than those with negative findings. These results suggested that patients with gastric cancer with larger pixel numbers might tend to show positive results with DWIBS/T2.

Conclusions: DWIBS/T2 and PET/CT have similar sensitivity for the diagnosis of upper gastrointestinal cancer. The diameter and depth of invasion affected the detectability of gastric cancer.

Keywords: Duodenal cancer; Gastric cancer; Gastrointestinal stromal tumor.

MeSH terms

  • Aged
  • Diffusion Magnetic Resonance Imaging*
  • Female
  • Fluorodeoxyglucose F18
  • Gastrointestinal Neoplasms / diagnosis*
  • Humans
  • Male
  • Multimodal Imaging*
  • Positron-Emission Tomography*
  • Radiopharmaceuticals
  • Reproducibility of Results
  • Retrospective Studies
  • Sensitivity and Specificity
  • Tomography, X-Ray Computed*
  • Upper Gastrointestinal Tract / diagnostic imaging
  • Upper Gastrointestinal Tract / pathology
  • Whole Body Imaging*


  • Radiopharmaceuticals
  • Fluorodeoxyglucose F18