Impact of Alzheimer's disease on the family caregiver's long-term quality of life: results from an ALSOVA follow-up study

Qual Life Res. 2016 Mar;25(3):687-97. doi: 10.1007/s11136-015-1100-x. Epub 2015 Sep 9.


Purpose: To examine caregivers' health-related quality of life (HRQoL) and well-being during the first 3 years after their family member's Alzheimer's disease (AD) diagnosis and assessed the relationship between caregivers' HRQoL, well-being, and the severity of AD. Further, to compare of caregivers' HRQoL to general population.

Methods: Longitudinal design (36 months) after AD diagnosis of 236 caregiver-patient dyads. Linear regression was used to assess age- and gender-adjusted association between repeated measurements of caregivers' HRQoL and the severity of AD. For comparison with general population, the National Health 2011 Health Examination Survey data was utilized.

Results: Caregivers had significantly lower HRQoL than age- and gender-standardized counterparts. Severity of AD was significantly (p < 0.05) associated with the mobility and depression dimensions of caregiver's HRQoL but not with the total HRQoL index score.

Conclusions: Caregivers' HRQoL seems to deteriorate earlier than previously noted. The severity of AD has not that great impact on caregiver's HRQoL as assumed.

Keywords: 15D; Alzheimer’s disease; Family caregivers; Health-related quality of life; Psychological distress.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Alzheimer Disease / nursing*
  • Caregivers / psychology*
  • Depressive Disorder / psychology
  • Family / psychology*
  • Female
  • Follow-Up Studies
  • Health Status*
  • Health Surveys
  • Humans
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Quality of Life / psychology*
  • Surveys and Questionnaires