Drug-Induced Hypersensitivity Syndrome Followed by Subacute Thyroiditis

Mika Sato; Yuki Mizuno; Kanako Matsuyama; En Shu; Hiroyuki Kanoh; Tetsuya Suwa; Mariko Seishima

doi:10.1159/000437251

Drug-Induced Hypersensitivity Syndrome Followed by Subacute Thyroiditis

Case Rep Dermatol. 2015 Jul 24;7(2):161-5. doi: 10.1159/000437251. eCollection 2015 May-Aug.

Authors

Mika Sato¹, Yuki Mizuno¹, Kanako Matsuyama¹, En Shu¹, Hiroyuki Kanoh¹, Tetsuya Suwa², Mariko Seishima¹

Affiliations

¹ Department of Dermatology, Gifu University Graduate School of Medicine, Gifu, Japan.
² Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan.

Abstract

Drug-induced hypersensitivity syndrome (DIHS) is a severe multiorgan system adverse drug reaction with reactivation of human herpesviruses (HHVs) such as HHV-6, HHV-7, cytomegalovirus (CMV) and Epstein-Barr virus. Various complications, including autoimmune diseases, sometimes appear during the course of DIHS. We report a case of salazosulfapyridine-induced DIHS associated with HHV-6 reactivation. Two and a half months after the onset of DIHS, subacute thyroiditis occurred, possibly associated with CMV reactivation. Prednisolone (20 mg/day) was effective for subacute thyroiditis. Long-term follow-up is needed in patients with DIHS because of the possible onset of autoimmune diseases.

Keywords: Cytomegalovirus; Drug rash with eosinophilia and systemic symptoms; Drug-induced hypersensitivity syndrome; Human herpesvirus 6; Subacute thyroiditis.

Publication types

Case Reports