Prostate-Type Adenocarcinoma in Mature Cystic Ovarian Teratoma

Int J Gynecol Pathol. 2016 Mar;35(2):185-90. doi: 10.1097/PGP.0000000000000217.


We report our experience with prostatic-type tissue in ovarian teratomas, and in particular we highlight a case of prostatic-type adenocarcinoma arising within a mature cystic ovarian teratoma in a 32-yr-old woman. On gross examination, the cyst consisted of typical features of a dermoid cyst. Closer examination revealed a single 1.5-cm solid nodule within the cyst. Microscopically, it was composed of a small cyst-like structure lined by urothelium and to one side glandular and stromal tissue consistent with prostate parenchyma. Within the prostatic-type tissue, there were malignant glands morphologically and immunohistochemically supportive of prostatic-type adenocarcinoma Gleason score 3+3=6. There were also areas consistent with high-grade prostatic intraepithelial neoplasia. Although there are several reports in the literature of benign prostatic-type tissue arising within ovarian as well as testicular teratomas, to our knowledge, prostatic-type adenocarcinoma arising in a mature ovarian teratoma is an extremely rare phenomenon, with only 1 previous report in the literature.

Publication types

  • Case Reports

MeSH terms

  • Adenocarcinoma / pathology*
  • Adult
  • Biomarkers, Tumor / analysis
  • Cell Transformation, Neoplastic / pathology*
  • Female
  • Humans
  • Immunohistochemistry
  • Male
  • Ovarian Neoplasms / pathology*
  • Prostatic Neoplasms / pathology*
  • Teratoma / pathology*


  • Biomarkers, Tumor

Supplementary concepts

  • Teratoma, Ovarian