Bacopa monniera Stabilized Silver Nanoparticles Attenuates Oxidative Stress Induced by Aluminum in Albino Mice

J Nanosci Nanotechnol. 2015 Feb;15(2):1101-9. doi: 10.1166/jnn.2015.8995.


In the recent years usage of nanomedicine plays a promising strategy in the improvement of medical treatment. The ecofriendly synthesized silver nanoparticles has introduced a new opportunity to increase the efficacy of drug by reducing its side effects. In the present study, we investigated the antioxidant property of Bacopa monniera stabilized silver nanoparticles against aluminum induced toxicity in albino mice. Forty male albino mice were randomly divided into five groups. First group was treated as control, second group received aluminum acetate (5 mg/kg b . w), third group received Bacopa monniera extract (5 mg/kg b . w), fourth group received BmSNPs (5 mg/kg b . w), fifth group received aluminum acetate plus BmSNPs. Exposure to aluminum acetate significantly increased lipid peroxidation levels with a significant decrease in the antioxidant enzymes such as superoxide dismutase, catalase and glutathione peroxidase activities in the brain, liver and kidney of mice. Degenerative changes were also observed in brain, liver and kidney of aluminum treated mice. No significant changes in the oxidative stress were observed in the Bacopa monniera and BmSNPs alone treated mice. Whereas, co-administration of BmSNPs to Al treated mice showed a significant decrease in lipid peroxidation levels with a significant increase of SOD, CAT and GPx indicating the antioxidant potential of nanoparticles and in counteracting Al induced oxidative stress and histological response in male albino mice. These findings clearly implicate that BmSNPs are able to eradicate the oxidative stress and prevent the tissue damage in aluminum exposed mice.

MeSH terms

  • Aluminum
  • Animals
  • Bacopa / chemistry*
  • Diffusion
  • Drug Stability
  • Drug Synergism
  • Excipients / chemistry
  • Male
  • Metal Nanoparticles / administration & dosage*
  • Metal Nanoparticles / chemistry
  • Metal Nanoparticles / ultrastructure
  • Mice
  • Organ Specificity / drug effects
  • Organ Specificity / immunology
  • Oxidative Stress / drug effects
  • Oxidative Stress / immunology
  • Particle Size
  • Plant Extracts / administration & dosage*
  • Plant Extracts / chemistry
  • Reactive Oxygen Species / immunology
  • Silver / administration & dosage*
  • Silver / chemistry
  • Systemic Inflammatory Response Syndrome / chemically induced
  • Systemic Inflammatory Response Syndrome / drug therapy*
  • Systemic Inflammatory Response Syndrome / immunology*
  • Tissue Distribution
  • Treatment Outcome


  • Excipients
  • Plant Extracts
  • Reactive Oxygen Species
  • Silver
  • Aluminum