[Severe complications after non-intended usage of octenidine dihydrochloride. A case series with four dogs]

Tierarztl Prax Ausg K Kleintiere Heimtiere. 2015;43(5):291-8. doi: 10.15654/TPK-150029. Epub 2015 Sep 10.
[Article in German]

Abstract

Objective: Case series of four dogs in which extensive bite wounds had been treated using octenidine dihydrochloride (Octenivet® or Octenisept®) flushing. The dogs subsequently developed severe local complications.

Material and methods: Retrospective evaluation of clinical symptoms, diagnostics, therapy and course of the disease.

Results: In four dogs, severe necrosis and persistent edematous changes of the treated area developed after the application of octenidine dihydrochloride. The clinical course was comparable to complications described previously in human medicine. Therapy was protracted and complicated by secondary wound infection.

Conclusion and clinical relevance: Irrigation of deep wounds, particularly bite wounds, using octenidine dihydrochloride without drainage may lead to persistent edematous changes, inflammatory reactions and necrosis. The inappropriate application of octenidine dihydrochloride for wound irrigation should be avoided in veterinary medicine.

Keywords: Wound; edema; necrosis; octenidine dihydrochloride; veterinary medicine.

Publication types

  • Case Reports

MeSH terms

  • Animals
  • Anti-Infective Agents, Local / administration & dosage
  • Anti-Infective Agents, Local / adverse effects*
  • Bites and Stings / drug therapy
  • Bites and Stings / veterinary*
  • Dog Diseases / chemically induced*
  • Dog Diseases / drug therapy*
  • Dogs
  • Edema / chemically induced
  • Edema / veterinary
  • Imines
  • Necrosis / chemically induced
  • Necrosis / veterinary
  • Pyridines / administration & dosage
  • Pyridines / adverse effects*
  • Retrospective Studies
  • Therapeutic Irrigation / adverse effects
  • Therapeutic Irrigation / methods
  • Therapeutic Irrigation / veterinary

Substances

  • Anti-Infective Agents, Local
  • Imines
  • Pyridines
  • octenidine