Regional Homogeneity (ReHo) Changes in New Onset Versus Chronic Benign Epilepsy of Childhood With Centrotemporal Spikes (BECTS): A Resting State fMRI Study

Epilepsy Res. 2015 Oct;116:79-85. doi: 10.1016/j.eplepsyres.2015.06.017. Epub 2015 Jul 10.

Abstract

Objective: The purpose of this study was to investigate regional homogeneity (ReHo) in children with new-onset drug-naïve Benign Epilepsy with Centrotemporal Spikes (BECTS), chronic BECTS and healthy controls (HC) using the Regional Homogeneity (ReHo) method applied to resting state fMRI data.

Methods: Resting state fMRI data was collected from three groups of children aged 6-13, including new onset drug naïve BECTS, chronic BECTS with medication, and HC; the data analyzed by ReHo method. Mandarin school exams scores were acquired and compared across groups.

Results: There were three main findings. Firstly, compared with HC, abnormally increased ReHo was observed in bilateral sensorimotor regions in new onset BECTS which normalized or even reversed in the chronic BECTS group. Secondly, enhanced ReHo was found in the left frontal language region in the two BECTS groups, with even higher ReHo value in the chronic group. Lastly, decreased ReHo was found in regions of the default mode network (DMN), bilateral occipital lobes and cerebellum in both the new onset and chronic BECTS groups, lower in chronic BECTS. Behavioral analyses of school scores showed the chronic BECTS group presented significantly lower scores compared to HC (p<.05).

Significance: The coherence of low frequency fluctuations is disrupted in sensorimotor, language and DMN-related regions in new-onset BECTS. Some of these effects seem to be selectively normalized in chronic BECTS, thus allowing us to explore possible chronicity and AED-induced effects on BECTS. Abnormal ReHo in left language and DMN regions could be responsible for impairments of cognitive function.

Keywords: BECTS; Epilepsy; Pediatric; Regional homogeneity; Resting state; fMRI.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age of Onset
  • Analysis of Variance
  • Anticonvulsants / therapeutic use
  • Brain / blood supply*
  • Brain / drug effects
  • Brain / physiopathology
  • Child
  • Chronic Disease
  • Epilepsy, Rolandic / drug therapy
  • Epilepsy, Rolandic / pathology*
  • Female
  • Humans
  • Image Processing, Computer-Assisted
  • Magnetic Resonance Imaging*
  • Male
  • Oxygen / blood
  • Rest*

Substances

  • Anticonvulsants
  • Oxygen