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. 2015 Oct;116:79-85.
doi: 10.1016/j.eplepsyres.2015.06.017. Epub 2015 Jul 10.

Regional Homogeneity (ReHo) Changes in New Onset Versus Chronic Benign Epilepsy of Childhood With Centrotemporal Spikes (BECTS): A Resting State fMRI Study

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Free PMC article

Regional Homogeneity (ReHo) Changes in New Onset Versus Chronic Benign Epilepsy of Childhood With Centrotemporal Spikes (BECTS): A Resting State fMRI Study

Hongwu Zeng et al. Epilepsy Res. .
Free PMC article

Abstract

Objective: The purpose of this study was to investigate regional homogeneity (ReHo) in children with new-onset drug-naïve Benign Epilepsy with Centrotemporal Spikes (BECTS), chronic BECTS and healthy controls (HC) using the Regional Homogeneity (ReHo) method applied to resting state fMRI data.

Methods: Resting state fMRI data was collected from three groups of children aged 6-13, including new onset drug naïve BECTS, chronic BECTS with medication, and HC; the data analyzed by ReHo method. Mandarin school exams scores were acquired and compared across groups.

Results: There were three main findings. Firstly, compared with HC, abnormally increased ReHo was observed in bilateral sensorimotor regions in new onset BECTS which normalized or even reversed in the chronic BECTS group. Secondly, enhanced ReHo was found in the left frontal language region in the two BECTS groups, with even higher ReHo value in the chronic group. Lastly, decreased ReHo was found in regions of the default mode network (DMN), bilateral occipital lobes and cerebellum in both the new onset and chronic BECTS groups, lower in chronic BECTS. Behavioral analyses of school scores showed the chronic BECTS group presented significantly lower scores compared to HC (p<.05).

Significance: The coherence of low frequency fluctuations is disrupted in sensorimotor, language and DMN-related regions in new-onset BECTS. Some of these effects seem to be selectively normalized in chronic BECTS, thus allowing us to explore possible chronicity and AED-induced effects on BECTS. Abnormal ReHo in left language and DMN regions could be responsible for impairments of cognitive function.

Keywords: BECTS; Epilepsy; Pediatric; Regional homogeneity; Resting state; fMRI.

Conflict of interest statement

DISCLOSURE

None of the authors has any conflict of interest to disclose. We confirm that we have read the Journal’s position on issues involved in ethical publication and affirm that this report is consistent with those guidelines.

Figures

Figure 1
Figure 1. New-onset drug-naïve BECTS vs. HC
Statistic t-map showing the difference between the new onset BECTS group and HC (two sample t-test, p < 0.005, voxel >10). Warm colors indicate new-onset group > HC, whereas cool colors indicate new-onset group < HC.
Figure 2
Figure 2. Chronic BECTS on AEDs vs HC
Statistic t-map showing the difference between the chronic BECTS group and HC (two sample t-test, p < 0.005, voxel >10). Warm colors indicate chronic > HC, whereas cool colors indicate chronic < HC.
Figure 3
Figure 3. Chronic vs. new-onset BECT groups
Statistic t-map showing the difference between the chronic group and new onset BECTS (two sample t-test, p < 0.005, voxel >10). Warm colors indicate chronic > new onset, whereas cool colors indicate chronic < new onset.

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