The linker for activation of T cells (LAT) signaling hub: from signaling complexes to microclusters

J Biol Chem. 2015 Oct 30;290(44):26422-9. doi: 10.1074/jbc.R115.665869. Epub 2015 Sep 9.


Since the cloning of the critical adapter, LAT (linker for activation of T cells), more than 15 years ago, a combination of multiple scientific approaches and techniques continues to provide valuable insights into the formation, composition, regulation, dynamics, and function of LAT-based signaling complexes. In this review, we will summarize current views on the assembly of signaling complexes nucleated by LAT. LAT forms numerous interactions with other signaling molecules, leading to cooperativity in the system. Furthermore, oligomerization of LAT by adapter complexes enhances intracellular signaling and is physiologically relevant. These results will be related to data from super-resolution microscopy studies that have revealed the smallest LAT-based signaling units and nanostructure.

Keywords: T-cell; adaptor protein; cooperativity; immunology; signal transduction.

Publication types

  • Research Support, N.I.H., Intramural
  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing* / chemistry
  • Adaptor Proteins, Signal Transducing* / immunology
  • Animals
  • Humans
  • Membrane Proteins* / chemistry
  • Membrane Proteins* / immunology
  • Multiprotein Complexes* / chemistry
  • Multiprotein Complexes* / immunology
  • Nanostructures / chemistry*
  • Nanostructures / ultrastructure
  • Protein Multimerization / immunology*
  • Signal Transduction / immunology*


  • Adaptor Proteins, Signal Transducing
  • LAT protein, human
  • Membrane Proteins
  • Multiprotein Complexes

Associated data

  • PDB/2GJ6