Assessment of a Comprehensive Anti-Aging Neck Cream

J Drugs Dermatol. 2015 Sep;14(9):997-1002.


Introduction: With many effective anti-aging solutions for the face, consumer focus is now turning to other parts of the body including the delicate skin on the neck. This study investigates the effect of a new neck cream on the appearance of texture, fine lines and wrinkles, laxity, and hydration.

Methods: 85 adult females ages 35-65 with Fitzpatrick skin types I through IV applied the test neck cream twice daily for a 3-month study period. Screening was conducted at Baseline, 2, 30, 60, and 90 days via a virtual trial. Subjects rated satisfaction in each of 4 anti-aging categories including hydration, texture, appearance of wrinkles, and appearance of laxity as well as three product attributes including application, feel, and smell.

Results: Improvement was statistically significant for all measured categories (hydration, texture, appearance of wrinkles, and appearance of laxity) with 94% of study subjects noting improvement in one or more of the measured categories. Further, the quantity of "Satisfied" and "Highly Satisfied" assessments increased 8-fold from baseline with a 94x increase in the quantity of "Highly Satisfied" assessments.

Discussion: The results demonstrate the product's rapid and continuing ability to improve the self-perceived signs of aging in the neck area including improvement in skin texture on the neck and a reduction in the appearance of wrinkles and laxity along the jawline. Future studies are recommended to determine the primary action mechanisms and to assess the degree of improvement by blinded physician assessment.

MeSH terms

  • Adult
  • Aged
  • Antioxidants / therapeutic use
  • Biotin / therapeutic use
  • Deanol / therapeutic use
  • Dermatologic Agents / therapeutic use
  • Drug Combinations
  • Female
  • Humans
  • Hyaluronic Acid / therapeutic use
  • Hygroscopic Agents / therapeutic use
  • Middle Aged
  • Monocyclic Sesquiterpenes
  • Neck
  • Patient Satisfaction
  • Sesquiterpenes / therapeutic use
  • Skin Aging / drug effects*
  • Skin Aging / pathology
  • Skin Aging / physiology
  • Skin Cream / therapeutic use*
  • Skin Physiological Phenomena / drug effects*
  • Vitamin B Complex / therapeutic use
  • Vitamin E / therapeutic use


  • Antioxidants
  • Dermatologic Agents
  • Drug Combinations
  • Hygroscopic Agents
  • Monocyclic Sesquiterpenes
  • Sesquiterpenes
  • Vitamin B Complex
  • Vitamin E
  • bisabolol
  • Deanol
  • Biotin
  • Hyaluronic Acid