Treatment Outcome in Depressed Latinos Predicted by Concomitant Psychosislike Symptoms

J Nerv Ment Dis. 2015 Oct;203(10):769-73. doi: 10.1097/NMD.0000000000000365.


We compared treatment response (≥50 decrease in Nine-Item Patient Health Questionnaire total score) among 24 Latinos with major depressive disorder, presenting with and without specific psychosislike symptoms: A, hearing noises or house sounds, B, hearing voices calling one's name, C, seeing fleeting visions such as shadows, and D, symptoms more likely to be truly psychotic (e.g., poorly defined and short-lasting voices [other than B], fleeting paranoid ideation, or fleeting ideas of reference). 18 subjects (75%) endorsed symptoms of cluster A, 12 (50%) of cluster B, 10 (31%) of cluster C, and 12 (50%) of cluster D. Only subjects who reported symptoms from the D cluster exhibited significantly unfavorable depressive outcomes (compared to those with absence of D symptoms). The authors propose a phenomenological differentiation between benign psychosislike symptoms (clusters A-C) and the expression of the psychotic continuum (cluster D) in depressed Latinos.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antidepressive Agents / therapeutic use
  • Antipsychotic Agents / therapeutic use
  • Case-Control Studies
  • Depressive Disorder, Major / complications
  • Depressive Disorder, Major / drug therapy
  • Depressive Disorder, Major / ethnology
  • Depressive Disorder, Major / psychology*
  • Female
  • Hispanic or Latino / psychology*
  • Humans
  • Male
  • Middle Aged
  • Psychotic Disorders / complications*
  • Psychotic Disorders / drug therapy
  • Psychotic Disorders / ethnology
  • Psychotic Disorders / psychology
  • Treatment Outcome


  • Antidepressive Agents
  • Antipsychotic Agents