Association of Meloxicam Use With the Risk of Acute Pancreatitis: A Case-Control Study

Clin Drug Investig. 2015 Oct;35(10):653-7. doi: 10.1007/s40261-015-0326-2.

Abstract

Background and objective: No sufficient research has focused on the relationship between meloxicam use and acute pancreatitis. This study aimed to explore this issue in Taiwan.

Methods: This case-control study was conducted using the database of the Taiwan National Health Insurance Program. In all, there were 6780 cases aged 20-84 years who were newly diagnosed with acute pancreatitis during the period 1998-2011, and 21,393 control subjects without acute pancreatitis. Cases and controls were matched for sex, age and comorbidities. Odds ratios (ORs) and 95% confidence intervals (CIs) were measured to explore the associations between acute pancreatitis, meloxicam use and comorbidities, using a multivariable unconditional logistic regression model.

Results: After controlling for potential confounding factors, the adjusted OR for acute pancreatitis was 1.76 (95% CI 1.30-2.40) for subjects with current use of meloxicam, in comparison with subjects who had never used meloxicam. The adjusted OR decreased to 1.29 (95% CI 0.82-2.03) for subjects with late use of meloxicam, but without statistical significance.

Conclusions: Current use of meloxicam is associated with increased odds of acute pancreatitis. Clinicians should consider the potential risk of acute pancreatitis when prescribing meloxicam.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Alcohol-Related Disorders / epidemiology*
  • Case-Control Studies
  • Comorbidity
  • Databases, Factual
  • Female
  • Gallstones / chemically induced
  • Gallstones / epidemiology*
  • Humans
  • Male
  • Meloxicam
  • Middle Aged
  • Pancreatitis / chemically induced
  • Pancreatitis / epidemiology*
  • Risk Factors
  • Taiwan / epidemiology
  • Thiazines / adverse effects*
  • Thiazoles / adverse effects*
  • Young Adult

Substances

  • Thiazines
  • Thiazoles
  • Meloxicam