Autologous Platelet Gel Improves Bone Reconstruction of Large Defects in Patients with Bone Giant Cell Tumors

In Vivo. Sep-Oct 2015;29(5):533-40.

Abstract

Background/aim: Giant cell tumors are mostly benign but locally aggressive tumors. The excision of bone tumors can result in large defects, therefore bone reconstruction is still one the most demanding procedures in orthopedic surgery. Our study addresses the opportunity for improving surgical outcome by employing β-tricalcium phosphate (β-TCP) with platelet-rich plasma (PRP) at the surgical site.

Patients and methods: We included 16 patients with giant cell tumors. After adjuvant therapy, the cavity was reconstructed with β-TCP, bone graft material (ActifuserR Granules Baxter) and platelet gel application.

Results: Our explorative analysis suggests a positive effect of PRP on surgical outcome in patients with giant cell tumors treated with curettage.

Conclusion: Use of platelet gel as an adjuvant significantly reduces the time required for bone healing following intralesional treatment of benign giant cell tumors, and achieves good functional results without promoting local recurrence.

Keywords: Giant cell tumor of bone; curettage; growth factors; loss of substance; platelet-rich plasma; regenerative medicine.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Blood Transfusion, Autologous*
  • Bone Neoplasms / diagnostic imaging
  • Bone Neoplasms / pathology*
  • Bone Neoplasms / therapy*
  • Curettage
  • Female
  • Follow-Up Studies
  • Giant Cell Tumor of Bone / diagnostic imaging
  • Giant Cell Tumor of Bone / pathology*
  • Giant Cell Tumor of Bone / therapy*
  • Humans
  • Male
  • Middle Aged
  • Neoplasm Grading
  • Neoplasm Recurrence, Local
  • Platelet Transfusion* / methods
  • Reconstructive Surgical Procedures*
  • Tomography, X-Ray Computed
  • Treatment Outcome
  • Young Adult