Releasing the Brakes on Cancer Immunotherapy

Cell. 2015 Sep 10;162(6):1186-90. doi: 10.1016/j.cell.2015.08.038.


This year's Lasker∼DeBakey Clinical Research Award goes to James Allison for discovering that antibody blockade of the T cell molecule CTLA-4 unleashes the body's immune response against malignant tumors. This has led to development of multiple "immune checkpoint therapies" that are prolonging and saving the lives of thousands of cancer patients.

Publication types

  • Biography
  • Historical Article

MeSH terms

  • Animals
  • Awards and Prizes
  • CTLA-4 Antigen
  • History, 20th Century
  • History, 21st Century
  • Humans
  • Immunotherapy / history*
  • Molecular Targeted Therapy
  • Neoplasms / immunology*
  • Neoplasms / therapy*
  • T-Lymphocytes / immunology
  • United States


  • CTLA-4 Antigen

Personal name as subject

  • James Allison