Challenges and opportunities for non-antibody scaffold drugs

Drug Discov Today. 2015 Oct;20(10):1271-83. doi: 10.1016/j.drudis.2015.09.004. Epub 2015 Sep 7.


The first candidates from the promising class of small non-antibody protein scaffolds are now moving into clinical development and practice. Challenges remain, and scaffolds will need to be further tailored toward applications where they provide real advantages over established therapeutics to succeed in a rapidly evolving drug development landscape.

Publication types

  • Review

MeSH terms

  • Animals
  • Drug Delivery Systems*
  • Drug Design*
  • Humans
  • Proteins / administration & dosage*
  • Proteins / pharmacology


  • Proteins