Safety Assessment of Pentaerythrityl Tetraesters as Used in Cosmetics

Int J Toxicol. 2015 Sep;34(2 Suppl):99S-112S. doi: 10.1177/1091581815596731.


The Cosmetic Ingredient Review (CIR) Expert Panel (Panel) reviewed the safety of 16 pentaerythrityl tetraester compounds as used in cosmetics. These ingredients mostly function as hair-conditioning agents, skin-conditioning agents-miscellaneous and binders, skin-conditioning agents-occlusive, viscosity-increasing agents-nonaqueous, and skin-conditioning agents-emollient. The Panel reviewed the available animal and human data related to these ingredients and previous safety assessments of the fatty acid moieties. The Panel concluded that pentaerythrityl tetraisostearate and the other pentaerythrityl tetraester compounds were safe in the practices of use and concentration as given in this safety assessment.

Keywords: cosmetics; pentaerythrityl tetraesters; safety.

MeSH terms

  • Consumer Product Safety*
  • Cosmetics / adverse effects*
  • Cosmetics / chemistry*
  • Esters / adverse effects*
  • Esters / chemistry*
  • Humans
  • Hydrocarbons, Chlorinated / adverse effects*
  • Hydrocarbons, Chlorinated / chemistry*
  • Risk Assessment


  • Cosmetics
  • Esters
  • Hydrocarbons, Chlorinated
  • pentaerythrityl tetrachloride