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. 2015 Sep 15;43(3):527-40.
doi: 10.1016/j.immuni.2015.08.011. Epub 2015 Sep 8.

BALB/c and C57BL/6 Mice Differ in Polyreactive IgA Abundance, Which Impacts the Generation of Antigen-Specific IgA and Microbiota Diversity

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BALB/c and C57BL/6 Mice Differ in Polyreactive IgA Abundance, Which Impacts the Generation of Antigen-Specific IgA and Microbiota Diversity

Floris Fransen et al. Immunity. .

Abstract

The interrelationship between IgAs and microbiota diversity is still unclear. Here we show that BALB/c mice had higher abundance and diversity of IgAs than C57BL/6 mice and that this correlated with increased microbiota diversity. We show that polyreactive IgAs mediated the entrance of non-invasive bacteria to Peyer's patches, independently of CX3CR1(+) phagocytes. This allowed the induction of bacteria-specific IgA and the establishment of a positive feedback loop of IgA production. Cohousing of mice or fecal transplantation had little or no influence on IgA production and had only partial impact on microbiota composition. Germ-free BALB/c, but not C57BL/6, mice already had polyreactive IgAs that influenced microbiota diversity and selection after colonization. Together, these data suggest that genetic predisposition to produce polyreactive IgAs has a strong impact on the generation of antigen-specific IgAs and the selection and maintenance of microbiota diversity.

Comment in

  • Independence Day for IgA.
    Macpherson AJ, McCoy KD. Macpherson AJ, et al. Immunity. 2015 Sep 15;43(3):416-8. doi: 10.1016/j.immuni.2015.08.024. Immunity. 2015. PMID: 26377894

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