Effects of Running on Chronic Diseases and Cardiovascular and All-Cause Mortality

Mayo Clin Proc. 2015 Nov;90(11):1541-52. doi: 10.1016/j.mayocp.2015.08.001. Epub 2015 Sep 8.


Considerable evidence has established the link between high levels of physical activity (PA) and all-cause and cardiovascular disease (CVD)-specific mortality. Running is a popular form of vigorous PA that has been associated with better overall survival, but there is debate about the dose-response relationship between running and CVD and all-cause survival. In this review, we specifically reviewed studies published in PubMed since 2000 that included at least 500 runners and 5-year follow-up so as to analyze the relationship between vigorous aerobic PA, specifically running, and major health consequences, especially CVD and all-cause mortality. We also made recommendations on the optimal dose of running associated with protection against CVD and premature mortality, as well as briefly discuss the potential cardiotoxicity of a high dose of aerobic exercise, including running (eg, marathons).

Publication types

  • Review

MeSH terms

  • Cardiovascular Diseases* / mortality
  • Cardiovascular Diseases* / physiopathology
  • Cardiovascular Diseases* / psychology
  • Chronic Disease
  • Humans
  • Mortality, Premature
  • Motor Activity
  • Running*