Amyloid β: Walking on the dark side of the moon

Mech Ageing Dev. 2015 Dec;152:1-4. doi: 10.1016/j.mad.2015.09.001. Epub 2015 Sep 8.

Abstract

For some decades, amyloid β (Aβ) has only been considered as a cytotoxic peptide, putative cause and marker of Alzheimer's disease (AD). Today, however, a considerable amount of evidence goes against the classical amyloid hypothesis and illustrates a new picture in which the Aβ loss of function, rather than its accumulation, has a pathogenic role in AD. In this concise review, we summarize some highlights of a collection of research pointing to the physiological function of Aβ and its role in the mechanisms of memory formation.

Keywords: Alzheimer’s disease; Amyloid β; Long term potentiation; Memory; cAMP.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alzheimer Disease / metabolism*
  • Alzheimer Disease / pathology
  • Alzheimer Disease / physiopathology
  • Amyloid beta-Peptides / metabolism*
  • Animals
  • Humans
  • Memory*

Substances

  • Amyloid beta-Peptides