Placental ADAMTS-12 Levels in the Pathogenesis of Preeclampsia and Intrahepatic Cholestasis of Pregnancy

Reprod Sci. 2016 Apr;23(4):475-81. doi: 10.1177/1933719115604730. Epub 2015 Sep 11.


Our aim was to determine whether placental A Disintegrin-like Metalloproteinase with ThromboSpondin motif 12 (ADAMTS-12), arylesterase (ARES) levels, total oxidant status (TOS), and total antioxidant status (TAS) differ in preeclampsia, intrahepatic cholestasis of pregnancy (ICP), and uncomplicated pregnancies or not. A prospective case-control study was carried out including 84 pregnant women (26 with ICP, 28 preeclamptic patients, and 30 healthy controls). Levels of ADAMTS-12, TAS, TOS, and ARES were studied in the supernatants of placental tissue homogenates. Placental ADAMTS-12 levels were distributed as 240.9 pg/mg in ICP, 289.7 pg/mg in preeclampsia, and 310.8 pg/mg in control groups. Levels of ADAMTS-12 (odds ratio = 6.509, 95% confidence interval:1.070-39.592, P = .042) in the placenta of the ICP were significantly lower than those in preeclampsia and control groups (P = .004), but no statistical significant difference was determined between preeclampsia and control groups. Decreased levels of placental ADAMTS-12 were found to be associated with ICP, suggesting a possible role of inflammation in the pathogenesis.

Keywords: ADAMTS-12; intrahepatic cholestasis of pregnancy; preeclampsia.

MeSH terms

  • ADAMTS Proteins / metabolism*
  • Adult
  • Case-Control Studies
  • Cholestasis, Intrahepatic / diagnosis*
  • Cholestasis, Intrahepatic / metabolism*
  • Female
  • Humans
  • Placenta / metabolism*
  • Placenta / pathology
  • Pre-Eclampsia / diagnosis*
  • Pre-Eclampsia / metabolism*
  • Pregnancy
  • Pregnancy Complications / diagnosis*
  • Pregnancy Complications / metabolism*
  • Prospective Studies
  • Young Adult


  • ADAMTS Proteins
  • ADAMTS12 protein, human

Supplementary concepts

  • Intrahepatic Cholestasis of Pregnancy