3D harmonic phase tracking with anatomical regularization

Med Image Anal. 2015 Dec;26(1):70-81. doi: 10.1016/j.media.2015.08.003. Epub 2015 Aug 24.


This paper presents a novel algorithm that extends HARP to handle 3D tagged MRI images. HARP results were regularized by an original regularization framework defined in an anatomical space of coordinates. In the meantime, myocardium incompressibility was integrated in order to correct the radial strain which is reported to be more challenging to recover. Both the tracking and regularization of LV displacements were done on a volumetric mesh to be computationally efficient. Also, a window-weighted regression method was extended to cardiac motion tracking which helps maintain a low complexity even at finer scales. On healthy volunteers, the tracking accuracy was found to be as accurate as the best candidates of a recent benchmark. Strain accuracy was evaluated on synthetic data, showing low bias and strain errors under 5% (excluding outliers) for longitudinal and circumferential strains, while the second and third quartiles of the radial strain errors are in the (-5%,5%) range. In clinical data, strain dispersion was shown to correlate with the extent of transmural fibrosis. Also, reduced deformation values were found inside infarcted segments.

Keywords: 3D tagged MR; Anatomical regularization; HARP; Monogenic phase; Myocardium incompressibility.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms*
  • Elastic Modulus / physiology
  • Elasticity Imaging Techniques / methods*
  • Heart Ventricles / anatomy & histology*
  • Humans
  • Image Enhancement / methods
  • Image Interpretation, Computer-Assisted / methods*
  • Imaging, Three-Dimensional / methods*
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Subtraction Technique
  • Ventricular Function, Left / physiology*