The Changing Epidemiology of Acinetobacter Spp. Producing OXA Carbapenemases Causing Bloodstream Infections in Brazil: A BrasNet Report

Diagn Microbiol Infect Dis. 2015 Dec;83(4):382-5. doi: 10.1016/j.diagmicrobio.2015.08.006. Epub 2015 Aug 12.

Abstract

We evaluated the epidemiology of Acinetobacter spp. recovered from patients diagnosed with bloodstream infections in 9 tertiary hospitals located in all Brazilian geographic regions between April and August 2014. Although OXA-23-producing Acinetobacter baumannii clones were disseminated in most hospitals, it was observed for the first time the spread of OXA-72 among clonally related A. baumannii isolated from distinct hospitals. Interestingly, Acinetobacter pittii was the most frequent species found in a Northern region hospital. Contrasting with the multisusceptible profile displayed by A. pittii isolates, the tetracyclines and polymyxins were the only antimicrobials active against all A. baumannii isolates.

Keywords: Acinetobacter spp; Bloodstream infections; Molecular epidemiology; OXA carbapenemase.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acinetobacter / classification
  • Acinetobacter / enzymology*
  • Acinetobacter / genetics
  • Acinetobacter / isolation & purification
  • Acinetobacter Infections / epidemiology*
  • Acinetobacter Infections / microbiology*
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Anti-Bacterial Agents / pharmacology
  • Bacteremia / epidemiology*
  • Bacteremia / microbiology*
  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism*
  • Brazil / epidemiology
  • Child
  • Child, Preschool
  • Cluster Analysis
  • Drug Resistance, Multiple, Bacterial
  • Female
  • Genotype
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Microbial Sensitivity Tests
  • Middle Aged
  • Molecular Typing
  • Polymerase Chain Reaction
  • Tertiary Care Centers
  • Young Adult
  • beta-Lactamases / genetics
  • beta-Lactamases / metabolism*

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • beta-Lactamases
  • carbapenemase