Stress-induced cardiac autonomic reactivity and preclinical atherosclerosis: does arterial elasticity modify the association?

Stress. 2015;18(6):622-30. doi: 10.3109/10253890.2015.1078307. Epub 2015 Sep 12.


The effect of acute mental stress on atherosclerosis can be estimated using arterial elasticity measured by carotid artery distensibility (Cdist). We examined the interactive effect of acute stress-induced cardiac reactivity and Cdist to preclinical atherosclerosis assessed by carotid intima-media thickness (IMT) in 58 healthy adults aged 24-39 years participated in the epidemiological Young Finns Study. Cdist and IMT were measured ultrasonographically. Impedance electrocardiography was used to measure acute mental stress-induced cardiac autonomic responses: heart rate (HR), respiratory sinus arrhythmia and pre-ejection period after the mental arithmetic and the public speaking tasks. Interactions between HR reactivity and Cdist in relation to preclinical atherosclerosis were found. The results imply that elevated HR reactivity to acute mental stress is related to less atherosclerosis among healthy participants with higher arterial elasticity. Possibly, increased cardiac reactivity in response to challenging tasks is an adaptive reaction related to better cardiovascular health.

Keywords: Acute mental stress; cardiovascular diseases; cardiovascular ultrasound; carotid artery distensibility; heart rate; intima-media thickness.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Atherosclerosis / diagnostic imaging
  • Atherosclerosis / physiopathology*
  • Autonomic Nervous System / diagnostic imaging
  • Autonomic Nervous System / physiopathology*
  • Carotid Arteries / diagnostic imaging
  • Carotid Arteries / physiopathology*
  • Carotid Intima-Media Thickness*
  • Elasticity
  • Electrocardiography
  • Female
  • Heart / physiopathology*
  • Heart Rate / physiology
  • Humans
  • Male
  • Risk Factors
  • Stress, Psychological / diagnostic imaging
  • Stress, Psychological / physiopathology*
  • Young Adult