New insights into the FLPergic complements of parasitic nematodes: Informing deorphanisation approaches

EuPA Open Proteom. 2014 Apr 19;3:262-272. doi: 10.1016/j.euprot.2014.04.002. eCollection 2014 Jun.

Abstract

FMRFamide-like peptide (FLP) receptors are appealing as putative anthelmintic targets. To date, 31 flp-encoding genes have been identified in Caenorhabditis elegans and thirteen FLP-activated G-protein coupled receptors (FLP-GPCRs) have been reported. The lack of knowledge on FLPs and FLP-GPCRs in parasites impedes their functional characterisation and chemotherapeutic exploitation. Using homology-based BLAST searches and phylogenetic analyses this study describes the identification of putative flp and flp-GPCR gene homologues in 17 nematode parasites providing the first pan-phylum genome-based overview of the FLPergic complement. These data will facilitate FLP-receptor deorphanisation efforts in the quest for novel control targets for nematode parasites.

Keywords: FLP; FLP-receptor; FMRFamide-like peptide; Nematode; Neuropeptide GPCR.