MiR-634 decreases cell proliferation and induces apoptosis by targeting mTOR signaling pathway in cervical cancer cells

Artif Cells Nanomed Biotechnol. 2016 Nov;44(7):1694-701. doi: 10.3109/21691401.2015.1080171. Epub 2015 Sep 14.


Taking the emergence of continuous resistance to chemotherapy and the evidence that miRNAs are associated with chemoresistance in cancers into consideration, it is of significant importance to reveal the miRNAs functions for the treatment of cancer. As a novel tumor suppressor, MiR-634 is known to induce apoptosis in tumor cell which is essential for tumorigenesis. Herein, we elucidated the regulation effects of miR-634 in gene expression and discovery of its target gene in cell proliferation and invasion that would aid therapeutic apoptosis. As a result, by targeting mTOR signal pathway, miR-634 inhibited cell proliferation, migration and invasiveness in cervical cancer cells and the block of miR-634 enhances the mTOR expression at both the mRNA and protein levels which regulated the expression of mTOR negatively. Taken together, these results further indicated that miR-634 is an effective target for cancer treatment, and the findings provided in this work might lead to the better understanding of the malignant behavior of cervical carcinoma.

Keywords: cell proliferation; cervical cancer; mTOR expression; microRNA.

MeSH terms

  • Adult
  • Apoptosis*
  • Cell Proliferation*
  • Female
  • Gene Expression Regulation, Neoplastic*
  • HeLa Cells
  • Humans
  • MicroRNAs / biosynthesis*
  • Middle Aged
  • Neoplasm Proteins / biosynthesis*
  • RNA, Neoplasm / biosynthesis*
  • Signal Transduction*
  • TOR Serine-Threonine Kinases / biosynthesis*
  • Uterine Cervical Neoplasms / metabolism*
  • Uterine Cervical Neoplasms / pathology


  • MIRN-634 microRNA, human
  • MicroRNAs
  • Neoplasm Proteins
  • RNA, Neoplasm
  • MTOR protein, human
  • TOR Serine-Threonine Kinases