The Journey to Establish CGRP as a Migraine Target: A Retrospective View

Headache. 2015 Oct;55(9):1249-55. doi: 10.1111/head.12656. Epub 2015 Sep 14.


In this retrospective, Dr. Lars Edvinsson recounts early steps and milestones in our understanding of the neuropeptide calcitonin gene-related peptide (CGRP) in the trigeminovascular system and its role in migraine. The discovery of the presence and function of CGRP and other neuropeptides in the cerebral vasculature and its sensory innervation is described. He relates the seminal finding that CGRP is uniquely released during migraine and the journey to develop blockers of CGRP effects. Now, over 30 years since its discovery, CGRP has become the target for a number of promising novel treatments for migraine patients.

Keywords: CGRP; migraine; review.

Publication types

  • Autobiography
  • Historical Article
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Calcitonin Gene-Related Peptide / history*
  • Calcitonin Gene-Related Peptide / physiology*
  • History, 20th Century
  • History, 21st Century
  • Humans
  • Migraine Disorders / history*
  • Migraine Disorders / physiopathology*
  • Neurology / history*
  • Retrospective Studies


  • Calcitonin Gene-Related Peptide

Personal name as subject

  • Lars Edvinsson