Nano-Snowflower of Gold Nanoparticles-Ruthenium Metallopolymer-Carbon Nanotubes Binding Anti-DNP IgE Antibody

J Nanosci Nanotechnol. 2015 Aug;15(8):5733-40. doi: 10.1166/jnn.2015.10303.

Abstract

Gold nanoparticles (AuNPs) have been chemically functionalized onto multiwalled carbon nanotubes (MWCNT) through a metallopolymer linker-bis (2,2':6'2"-terpyridine) ruthenium(II)-connected diblock poly(N-isopropyacryamide). A "nano-snowflower" pattern was formed by self-assembly MWCNT-AuNP nanocomposite with anti-DNP IgE antibody. MWCNT-AuNP nanohybrid has unique biocompatibility and electronic current-voltage properties. This nanohybrid shows the potential application for IgE biosensor to diagnose cancer cells. We represent a step towards building complex electronic circuits response by providing molecular recognition properties.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adsorption
  • Antibodies, Monoclonal / chemistry
  • Antibodies, Monoclonal / immunology*
  • Conductometry / instrumentation
  • Electric Conductivity
  • Equipment Design
  • Equipment Failure Analysis
  • Gold / chemistry*
  • Immunoassay / instrumentation*
  • Immunoglobulin E / analysis
  • Immunoglobulin E / immunology*
  • Materials Testing
  • Metal Nanoparticles / chemistry*
  • Nanocomposites / chemistry
  • Nanocomposites / ultrastructure
  • Particle Size
  • Protein Binding
  • Ruthenium / chemistry*
  • Surface Properties

Substances

  • Antibodies, Monoclonal
  • Immunoglobulin E
  • Gold
  • Ruthenium