Impact of single-dose nandrolone decanoate on gonadotropins, blood lipids and HMG CoA reductase in healthy men

Andrologia. 2016 Jun;48(5):595-600. doi: 10.1111/and.12488. Epub 2015 Sep 15.


The aim was to study the effect and time profile of a single dose of nandrolone decanoate (ND) on gonadotropins, blood lipids and HMG CoA reductase [3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGCR)] in healthy men. Eleven healthy male participants aged 29-46 years were given a single dose of 150 mg ND as an intramuscular dose of Deca Durabol®, Organon. Blood samples for sex hormones, lipids and HMGCR mRNA analysis were collected prior to ND administration day 0, 4 and 14. A significant suppression of luteinising hormone (LH) and follicle-stimulating hormone (FSH) was seen after 4 days. Total testosterone and bioavailable testosterone level decreased significantly throughout the observed study period. A small but significant decrease in sexual hormone-binding globulin (SHBG) was seen after 4 days but not after 14 days. Total serum (S)-cholesterol and plasma (P)-apolipoprotein B (ApoB) increased significantly after 14 days. In 80% of the individuals, the HMGCR mRNA level was increased 4 days after the ND administration. Our results show that a single dose of 150 mg ND increases (1) HMGCR mRNA expression, (2) total S-cholesterol and (3) P-ApoB level. The long-term consequences on cardiovascular risk that may appear in users remain to be elucidated.

Keywords: Blood lipids; HMG CoA reductase; gonadotropins; nandrolone decanoate.

MeSH terms

  • Adult
  • Anabolic Agents / administration & dosage*
  • Anabolic Agents / adverse effects*
  • Apolipoproteins B / blood
  • Cardiovascular Diseases / etiology
  • Cholesterol / blood
  • Follicle Stimulating Hormone / blood
  • Gonadotropins / blood*
  • Humans
  • Hydroxymethylglutaryl CoA Reductases / genetics*
  • Lipids / blood*
  • Luteinizing Hormone / blood
  • Male
  • Middle Aged
  • Nandrolone / administration & dosage
  • Nandrolone / adverse effects
  • Nandrolone / analogs & derivatives*
  • Nandrolone Decanoate
  • RNA, Messenger / blood
  • RNA, Messenger / genetics
  • Risk Factors


  • Anabolic Agents
  • Apolipoproteins B
  • Gonadotropins
  • Lipids
  • RNA, Messenger
  • Nandrolone
  • Luteinizing Hormone
  • Follicle Stimulating Hormone
  • Cholesterol
  • HMGCR protein, human
  • Hydroxymethylglutaryl CoA Reductases
  • Nandrolone Decanoate