Improving healthspan via changes in gut microbiota and fermentation

Age (Dordr). 2015 Oct;37(5):98. doi: 10.1007/s11357-015-9817-6. Epub 2015 Sep 14.


Dietary resistant starch impact on intestinal microbiome and improving healthspan is the topic of this review. In the elderly population, dietary fiber intake is lower than recommended. Dietary resistant starch as a source of fiber produces a profound change in gut microbiota and fermentation in animal models of aging. Dietary resistant starch has the potential for improving healthspan in the elderly through multiple mechanisms as follows: (1) enhancing gut microbiota profile and production of short-chain fatty acids, (2) improving gut barrier function, (3) increasing gut peptides that are important in glucose homeostasis and lipid metabolism, and (4) mimicking many of the effects of caloric restriction including upregulation of genes involved in xenobiotic metabolism.

Keywords: Age-related anorexia; Butyrate; Caloric restriction mimetic; Gut health; Gut microbiota; Gut peptides; Healthspan; Prebiotic; Resistant starch; Short-chain fatty acids.

Publication types

  • Review

MeSH terms

  • Aging / physiology*
  • Animals
  • Diet*
  • Fermentation / physiology*
  • Gastrointestinal Microbiome / physiology*
  • Gastrointestinal Tract / microbiology*
  • Humans