The pro-inflammatory and anti-inflammatory cytokine profile in peripheral blood of women with recurrent implantation failure

Reprod Biomed Online. 2015 Dec;31(6):823-6. doi: 10.1016/j.rbmo.2015.08.009. Epub 2015 Aug 21.

Abstract

Limited information is available on the balance state of pro- and anti-inflammatory cytokines in patients with recurrent implantation failure (RIF). This study assessed the pro- and anti-inflammatory cytokines in plasma of 34 patients with RIF, compared with those of 25 women with a successful pregnancy in the first IVF/intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET) cycle. The IFN-γ, IL-1β, IL-6 and IL-4 concentrations were higher, whereas the TGF-β1 concentration was lower in the RIF group compared with the control group. Furthermore, the ratios of pro-inflammatory and anti-inflammatory cytokines IFN-γ/IL-4, IFN-γ/IL-10, IFN-γ/TGF-β1, IL-6/IL-10, IL-6/TGF-β1, IL-1β/TGF-β1 and TNF-α/TGF-β1 were higher in the RIF group (all P < 0.01). The results suggested a shift toward a pro-inflammatory state in peripheral blood of the patients with RIF.

Keywords: IVF/ICSI–ET; anti-inflammatory cytokines; pro-inflammatory cytokines; recurrent implantation failure.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abortion, Habitual / blood*
  • Abortion, Habitual / epidemiology
  • Adult
  • Anti-Inflammatory Agents / blood*
  • Case-Control Studies
  • Cytokines / blood*
  • Embryo Implantation
  • Embryo Loss / blood
  • Embryo Loss / epidemiology
  • Female
  • Fertilization in Vitro / methods
  • Humans
  • Inflammation Mediators / blood*
  • Male
  • Pregnancy
  • Sperm Injections, Intracytoplasmic

Substances

  • Anti-Inflammatory Agents
  • Cytokines
  • Inflammation Mediators