Pulsed dye laser versus long pulsed Nd:YAG laser in the treatment of angiokeratoma of Fordyce: A randomized, comparative, observer-blinded study

J Dermatolog Treat. 2016;27(3):270-4. doi: 10.3109/09546634.2015.1094180. Epub 2015 Oct 7.


Background: Angiokeratoma of Fordyce is typically asymptomatic, blue-to-red papules with a scaly surface located on the scrotum, shaft of penis or labia majora. They can be treated with some locally destructive treatment modalities such as excision, electrocoagulation, cryotherapy and laser.

Objectives: To compare the effects of the pulsed dye laser versus long pulsed Nd:YAG laser in the treatment of angiokeratoma of Fordyce.

Methods: Twenty tow patients with angiokeratoma of Fordyce were included in this study. All participants received three sessions of pulsed dye laser on the selected side or part of lesional area and long pulsed Nd:YAG laser on the other side or part of lesional area. Two dermatologists independently evaluated the photographs of the baseline and two-month follow-up after last session using a grade system in which treatment response was categorized into six grades.

Results: Both PDL and long pulsed Nd:YAG laser revealed statistically significant improvements in angiokeratoma of fordyce. Comparatively, there was a statistical difference between them (overall mean improvement with PDL, 61.8%, versus Nd:YAG, 77.63%; p < 0.005).

Conclusions: Both PDL and 1064-nm Nd:YAG laser are effective and safe in the treatment of angiokeratoma of Fordyce with better response in Nd:YAG laser than pulsed dye laser.

Keywords: Angiokeratoma; Nd:YAG; PDL.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Angiokeratoma / pathology
  • Angiokeratoma / radiotherapy*
  • Double-Blind Method
  • Female
  • Genital Neoplasms, Female / pathology
  • Genital Neoplasms, Female / radiotherapy*
  • Genital Neoplasms, Male / pathology
  • Genital Neoplasms, Male / radiotherapy*
  • Humans
  • Lasers, Dye / therapeutic use*
  • Lasers, Solid-State / therapeutic use*
  • Low-Level Light Therapy / methods*
  • Male
  • Skin Neoplasms / pathology
  • Skin Neoplasms / radiotherapy*
  • Young Adult