Development of Next-Generation Immunomodulatory Antibodies for Cancer Therapy through Optimization of the IgG Framework

Cancer Cell. 2015 Sep 14;28(3):273-5. doi: 10.1016/j.ccell.2015.08.008.


In this issue of Cancer Cell, Dahan and colleagues demonstrate that the Fc region has a significant impact on the therapeutic capacity of checkpoint inhibitor antibodies targeting the PD-1/PD-L1 axis in pre-clinical tumor models. This work provides important insights with respect to the further clinical development of checkpoint inhibitors.

Publication types

  • Comment

MeSH terms

  • Animals
  • Antibodies / immunology*
  • B7-H1 Antigen / immunology*
  • Neoplasms / immunology*
  • Programmed Cell Death 1 Receptor / immunology*
  • Receptors, IgG / immunology*


  • Antibodies
  • B7-H1 Antigen
  • Programmed Cell Death 1 Receptor
  • Receptors, IgG