Prognostic value of forced expiratory volume in 1 second/forced vital capacity in idiopathic pulmonary fibrosis

Chron Respir Dis. 2016 Feb;13(1):40-7. doi: 10.1177/1479972315603714. Epub 2015 Sep 15.


Emphysema on high-resolution computed tomography of the chest is the recent focus in the general practice in idiopathic pulmonary fibrosis (IPF). However, adequate attention has not been paid to obstructive disorder. Therefore, we retrospectively evaluated the association between the degree of airway obstruction and longevity in IPF subjects, with a hypothesis that lower forced expiratory volume in 1 second (FEV1)/forced vital capacity (FVC) has an impact on prognosis. One hundred and fourteen consecutive IPF subjects who had been diagnosed with IPF and had undergone evaluation including pulmonary function test from January 2008 to May 2013 were included in the study. The relationship between baseline data and survival was examined. FEV1/FVC was widely distributed, ranging from 48.6% to 100%. On both univariate and multivariate Cox's regression analyses, lower FEV1/FVC was significantly associated with better survival (hazard ratio of 1.07 and 1.04 and 95% confidential interval of 1.03-1.10 and 1.01-1.08, respectively). Even on analysis with backward selection, FEV1/FVC remained a significant prognostic factor. FEV1/FVC is widely distributed and negatively predicts survival in IPF. A FEV1/FVC should be assessed in "real-world" general practice. Also, the effect of smoking on the clinical course of IPF should be investigated further.

Keywords: FEV1/FVC; idiopathic pulmonary fibrosis; interstitial; lung disease; obstructive; prognosis.

MeSH terms

  • Forced Expiratory Volume*
  • Humans
  • Prognosis
  • Pulmonary Fibrosis / mortality
  • Pulmonary Fibrosis / physiopathology*
  • Regression Analysis
  • Retrospective Studies
  • Vital Capacity*