On-demand drug delivery from local depots

J Control Release. 2015 Dec 10;219:8-17. doi: 10.1016/j.jconrel.2015.09.011. Epub 2015 Sep 14.


Stimuli-responsive polymeric depots capable of on-demand release of therapeutics promise a substantial improvement in the treatment of many local diseases. These systems have the advantage of controlling local dosing so that payload is released at a time and with a dose chosen by a physician or patient, and the dose can be varied as disease progresses or healing occurs. Macroscale drug depot can be induced to release therapeutics through the action of physical stimuli such as ultrasound, electric and magnetic fields and light as well as through the addition of pharmacological stimuli such as nucleic acids and small molecules. In this review, we highlight recent advances in the development of polymeric systems engineered for releasing therapeutic molecules through physical and pharmacological stimulation.

Keywords: Depot; Drug delivery; Electric; Light; Magnetic; Nucleic acid; On-demand; Pharmaceutical; Polymer; Stimulated; Therapeutic; Ultrasound.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Delayed-Action Preparations / administration & dosage
  • Delayed-Action Preparations / chemistry
  • Drug Delivery Systems*
  • Humans
  • Pharmaceutical Preparations / administration & dosage
  • Pharmaceutical Preparations / chemistry
  • Polymers / administration & dosage
  • Polymers / chemistry


  • Delayed-Action Preparations
  • Pharmaceutical Preparations
  • Polymers