Calcium signaling as a mediator of cell energy demand and a trigger to cell death

Ann N Y Acad Sci. 2015 Sep;1350(1):107-16. doi: 10.1111/nyas.12885.

Abstract

Calcium signaling is pivotal to a host of physiological pathways. A rise in calcium concentration almost invariably signals an increased cellular energy demand. Consistent with this, calcium signals mediate a number of pathways that together serve to balance energy supply and demand. In pathological states, calcium signals can precipitate mitochondrial injury and cell death, especially when coupled to energy depletion and oxidative or nitrosative stress. This review explores the mechanisms that couple cell signaling pathways to metabolic regulation or to cell death. The significance of these pathways is exemplified by pathological case studies, such as those showing loss of mitochondrial calcium uptake 1 in patients and ischemia/reperfusion injury.

Keywords: MICU1; calcium signaling; cell death; ischemia/reperfusion injury; mitochondrial calcium uptake; mitochondrial permeability transition pore.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Apoptosis
  • Calcium Signaling*
  • Calcium-Binding Proteins / genetics
  • Calcium-Binding Proteins / metabolism
  • Cation Transport Proteins / genetics
  • Cation Transport Proteins / metabolism
  • Cell Death*
  • Energy Metabolism*
  • Humans
  • Mitochondria / metabolism*
  • Mitochondria / pathology
  • Mitochondrial Membrane Transport Proteins / genetics
  • Mitochondrial Membrane Transport Proteins / metabolism
  • Mitochondrial Membranes / chemistry
  • Mitochondrial Membranes / metabolism
  • Mitochondrial Membranes / pathology
  • Mitochondrial Proteins / genetics
  • Mitochondrial Proteins / metabolism
  • Models, Biological*
  • Mutation
  • Necrosis
  • Permeability
  • Phosphate Transport Proteins / genetics
  • Phosphate Transport Proteins / metabolism
  • Porosity

Substances

  • Calcium-Binding Proteins
  • Cation Transport Proteins
  • MICU1 protein, human
  • Mitochondrial Membrane Transport Proteins
  • Mitochondrial Proteins
  • Phosphate Transport Proteins
  • SLC25A3 protein, human