The development of SERI® Surgical Scaffold, an engineered biological scaffold

Ann N Y Acad Sci. 2015 Nov;1358:44-55. doi: 10.1111/nyas.12886. Epub 2015 Sep 16.


The primary goal of reconstructive and revision surgery is to restore, repair, rebuild, and support damaged, weakened, or absent tissue. There are numerous approaches for soft tissue support and repair, including the use of autologous tissue, human- or animal-derived acellular dermal matrices, absorbable or permanent synthetic mesh, and, now, a new class of bioresorbable protein scaffold. Although many factors influence the choice of surgical approach and the specific product used for soft tissue support and repair, the goal is to improve long-term outcomes while minimizing complications and recurrences requiring further revisional surgery. In this review, the basic science, clinical characteristics, and clinical applications of SERI(®) Surgical Scaffold, a novel, engineered, highly purified silk product for soft tissue support and repair will be presented.

Keywords: SERI® Surgical Scaffold; abdominal wall reconstruction; breast revision; highly purified silk; soft tissue support.

Publication types

  • Review

MeSH terms

  • Animals
  • Bioengineering
  • Humans
  • Silk*
  • Surgical Mesh*
  • Tissue Scaffolds
  • Wound Healing


  • Silk