Optimization of dose of collagen hydrolysate to prevent UVB-irradiated skin damage

Biosci Biotechnol Biochem. 2016;80(2):356-9. doi: 10.1080/09168451.2015.1086258. Epub 2015 Sep 17.

Abstract

Collagen hydrolysate (CH) was orally administered to UVB-irradiated hairless mice at doses of 20, 200-2000 mg/kg BW/day. The low dose of CH increased the skin hydration and reduced the transepidermal water loss on damaged skin. These results suggested the optimal dose of collagen to improve the UV-damaged skin condition.

Keywords: TEWL (Transepidermal water loss); collagen hydrolysate; hyaluronic acid; skin hydration.

MeSH terms

  • Administration, Oral
  • Animals
  • Collagen / chemistry
  • Dose-Response Relationship, Drug
  • Drug Dosage Calculations
  • Hydrolysis
  • Male
  • Mice
  • Mice, Hairless
  • Peptide Fragments / pharmacology*
  • Skin / drug effects*
  • Skin / metabolism
  • Skin / pathology
  • Skin / radiation effects
  • Skin Aging / drug effects*
  • Skin Aging / radiation effects
  • Ultraviolet Rays / adverse effects
  • Water / metabolism
  • Water Loss, Insensible / drug effects*
  • Water Loss, Insensible / radiation effects

Substances

  • Peptide Fragments
  • Water
  • Collagen