Stressed-Out Endoplasmic Reticulum Inflames the Mitochondria

Immunity. 2015 Sep 15;43(3):409-11. doi: 10.1016/j.immuni.2015.08.027.

Abstract

Bacterial infection induces inflammasome activation and release of interleukin-1 (IL-1) cytokines. Bronner et al. (2015) show that during Brucella abortus infection, an endoplasmic reticulum stress sensor, IRE1α, initiates NLRP3- and caspase-2-mediated mitochondrial damage that potentiates NLRP3 inflammasome assembly.

Publication types

  • Comment

MeSH terms

  • Animals
  • Carrier Proteins / immunology*
  • Caspase 2 / immunology*
  • Endoplasmic Reticulum Stress / immunology*
  • Humans
  • Inflammasomes / immunology*
  • Mitochondria / immunology*

Substances

  • Carrier Proteins
  • Inflammasomes
  • Caspase 2