Targeting the glucocorticoid receptor in breast and prostate cancers

Sci Transl Med. 2015 Sep 16;7(305):305ps19. doi: 10.1126/scitranslmed.aac7531.


Steroid receptors for androgens and estrogens have essential roles in prostate and breast cancers. Recently, glucocorticoid receptor (GR) activity has also been proposed as having an important role in these cancers. Underscoring the cooperative nature of nuclear receptor activity, data now suggest that GR function in prostate and breast cancers is dependent on the tumor's concomitant androgen or estrogen receptor activity.

MeSH terms

  • Animals
  • Breast Neoplasms / drug therapy
  • Breast Neoplasms / metabolism*
  • Cell Survival
  • Estrogen Receptor alpha / metabolism
  • Female
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Male
  • Prognosis
  • Prostatic Neoplasms / drug therapy
  • Prostatic Neoplasms / metabolism*
  • Receptors, Androgen / metabolism
  • Receptors, Glucocorticoid / metabolism*
  • Signal Transduction
  • Translational Research, Biomedical


  • AR protein, human
  • ESR1 protein, human
  • Estrogen Receptor alpha
  • Receptors, Androgen
  • Receptors, Glucocorticoid